Epithalon

Epithalon is primarily used in research as a model peptide for studying fundamental biological mechanisms. In laboratory settings, researchers employ it to:

• Conduct binding and molecular interaction studies to understand how short peptides engage with proteins, DNA, and other cellular targets.
• Explore its role as a gene-regulatory peptide, monitoring transcriptional activity and protein synthesis in experimental systems.
• Investigate chromatin structure and nuclear function, focusing on how Epithalon influences DNA organization and cell cycle regulation.

• Neurobiology: Studying potential influences on neurogenesis, neural differentiation, and peptide-mediated protein expression.
• Genetics and epigenetics: Examining how short peptides may affect telomere biology, chromatin remodeling, and epigenetic regulation.
• Cellular aging models: Observing oxidative stress responses, DNA repair mechanisms, and cellular senescence pathways.

Based on the available preclinical data, the most common side effects associated with Epithalon treatment include:

• Injection site reactions (redness, minor swelling) in animal models
• Transient changes in melatonin levels observed in pineal gland studies
• Mild fluctuations in thyroid-stimulating hormone in preclinical experiments

Note: The safety profile of Epithalon has not been fully established, and further clinical studies are needed to fully evaluate the potential for side effects and long-term safety of Epithalon in mammals.

Epithalon is a synthetic tetrapeptide (AEDG) used in controlled laboratory investigations. It supports studies into peptide interactions, cellular signaling, and gene expression models. Designed strictly for research use, it enables experiments focused on chromatin biology, cellular aging, and peptide stability in experimental settings. This product is intended solely for in vitro and preclinical research use. No conclusions can be drawn regarding safety, efficacy, or therapeutic use in humans.

1. Yue X, et al. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY). 2022.
2. Kossoy G, et al. Epitalon and colon carcinogenesis in rats. Int J Mol Med. 2003.
3. Sibarov DA, et al. Epitalon influences pineal secretion in stress-exposed rats. Neuro Endocrinol Lett. 2002.
4. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002.
5. Khavinson V, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis. Molecules. 2020.
6. Khavinson VK, et al. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev. 2000.
7. Anisimov VN, et al. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett. 2002.
8. Sibarov DA, et al. Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. Neurosci Behav Physiol. 2007.
9. Khavinson V, et al. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuro Endocrinol Lett. 2002.
10. Anisimov VN, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003.
11. Khavinson VKh, et al. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003.
12. Vanhee C, et al. Identification of the small research tetra peptide Epitalon. Drug Test Anal. 2015.
13. Vinogradova IA. Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity. Adv Gerontol. 2009.

All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration. Neither the products described nor the company are intended to diagnose, treat, cure, or prevent any disease.